PBPK Models
1. Lin Z, Li M, Gehring R, Riviere JE. Development and application of a multiroute physiologically based pharmacokinetic model for oxytetracycline in dogs and humans. Journal of Pharmaceutical Sciences. 2015;104(1):233-43. doi: 10.1002/jps.24244. Access Model Code | Link to Article
2. Huang L, Lin Z, Zhou X, Zhu M, Gehring R, Riviere JE, Yuan Z. Estimation of residue depletion of cyadox and its marker residue in edible tissues of pigs using physiologically based pharmacokinetic modelling. Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment. 2015;32(12):2002-17. doi: 10.1080/19440049.2015.1100330. Access Model Code | Link to Article | Link to PDF file
3. Lin Z, Monteiro-Riviere NA, Riviere JE. A physiologically based pharmacokinetic model for polyethylene glycol-coated gold nanoparticles of different sizes in adult mice. Nanotoxicology. 2016;10(2):162-72. doi: 10.3109/17435390.2015.1027314. Access Model Code | Link to Article | Link to PDF file
4. Lin Z, Monteiro-Riviere NA, Kannan R, Riviere JE. A computational framework for interspecies pharmacokinetics, exposure and toxicity assessment of gold nanoparticles. Nanomedicine (Lond). 2016;11(2):107-19. doi: 10.2217/nnm.15.177. Access Model Code | Link to Article | Link to PDF file
5. Lin Z, Vahl CI, Riviere JE. Human food safety implications of variation in food animal drug metabolism. Scientific Reports. 2016;6:27907. doi: 10.1038/srep27907. Access Model Code | Link to Article | Link to PDF file
6. Lin Z, Jaberi-Douraki M, He C, Jin S, Yang RSH, Fisher JW, Riviere JE. Performance assessment and translation of physiologically based pharmacokinetic models from acslX to Berkeley Madonna, MATLAB, and R language: oxytetracycline and gold nanoparticles as case examples. Toxicological Sciences, 2017;158(1):23-35. doi: https://doi.org/10.1093/toxsci/kfx070. [PMID: 28402537] Access Model Code | Link to Article | Link to PDF file
7. Li M, Gehring R, Riviere JE, Lin Z. Development and application of a population physiologically based pharmacokinetic model for penicillin G in swine and cattle for food safety assessment. Food and Chemical Toxicology, 2017;107:74-87. doi: 10.1016/j.fct.2017.06.023. [PMID: 28627373] Access Model Code | Link to Article | Link to PDF file
8. Zeng D, Lin Z, Fang B, Li M, Gehring R, Riviere JE, Zeng Z. Pharmacokinetics of mequindox and its marker residue 1,4-bisdesoxymequindox in swine following multiple oral gavage and intramuscular administration: an experimental study coupled with population physiologically based pharmacokinetic modeling. Journal of Agricultural and Food Chemistry, 2017;65(28):5768-5777. doi: 10.1021/acs.jafc.7b01740. [PMID: 28640606] Access Model Code | Link to Article | Link to PDF file
9. Cheng YH, Riviere JE, Monteiro-Riviere NA, Lin Z. (2018). Probabilistic risk assessment of gold nanoparticles after intravenous administration by integrating in vitro and in vivo toxicity with physiologically based pharmacokinetic modeling. Nanotoxicology, 12(5):453-469. [PMID: 29658401] Access Model Code | Link to Article | Link to PDF file
10. Li M, Gehring R, Riviere JE, Lin Z. (2018). Probabilistic physiologically based pharmacokinetic model for penicillin G in milk from dairy cows following intramammary or intramuscular administrations. Toxicological Sciences, 164(1):85-100. [PMID: 29945226] Access Model Code | Link to Article | Link to PDF file
11. Elwell-Cuddy T, Li M, KuKanich B, Lin Z. (2018). The construction and application of a population physiologically based pharmacokinetic model for methadone in Beagles and Greyhounds. Journal of Veterinary Pharmacology and Therapeutics, 41(5):670-683. [PMID: 29923612] Access Model Code | Link to Article | Link to PDF file
12. Zeng D, Lin Z, Zeng Z, Fang B, Li M, Cheng YH, Sun Y. (2019). Assessing Global Human Exposure to T-2 Toxin via Poultry Meat Consumption Using a Lifetime Physiologically Based Pharmacokinetic Model. Journal of Agricultural and Food Chemistry, 67(5):1563-1571. [PMID: 30633497] Access Model Code | Link to Article | Link to PDF file
13. Li M, Mainquist-Whigham C, Karriker LA, Wulf LW, Zeng D, Gehring R, Riviere JE, Coetzee JF, Lin Z. (2019). An integrated experimental and physiologically based pharmacokinetic modeling study of penicillin G in heavy sows. Journal of Veterinary Pharmacology and Therapeutics, 42(4):461-475. [PMID: 31012501] Access Model Code | Link to Article | Link to PDF file
14. Li M, Cheng YH, Chittenden JT, Baynes RE, Tell LA, Davis JL, Vickroy TW, Riviere JE, Lin Z. (2019). Integration of Food Animal Residue Avoidance Databank (FARAD) empirical methods for drug withdrawal interval determination with a mechanistic population-based interactive physiologically-based pharmacokinetic (iPBPK) modeling platform: example for flunixin meglumine administration. Archives of Toxicology, 93(7):1865-1880. [PMID: 31025081] Access Model Code | Link to Article | Link to PDF file
15. Chou WC, Lin Z. (2019). Bayesian Evaluation of a Physiologically Based Pharmacokinetic (PBPK) Model for Perfluorooctane Sulfonate (PFOS) to Characterize the Interspecies Uncertainty between Mice, Rats, Monkeys, and Humans: Development and Performance Verification. Environment International, 129:408-422. [PMID: 31152982] Access Model Code | Link to Article | Link to PDF file
16. Lin YJ, Cheng CJ, Chen JW,Lin Z. (2020). Incorporating exogenous and endogenous exposures into dietary risk assessment of nitrate and nitrite in vegetables: a probabilistic integrated toxicokinetic modeling approach. Journal of Agricultural and Food Chemistry, 68(4):1079-1090. [PMID: 31885263] Access Model Code | Link to Article | Link to PDF file
17. Xu N, Li M, Chou WC, Lin Z. (2020). A physiologically based pharmacokinetic model of doxycycline for predicting tissue residues and withdrawal intervals in grass carp (Ctenopharyngodon idella). Food and Chemical Toxicology, 137, 111127. [PMID: 31945393] Access Model Code | Link to Article | Link to PDF file
18. Chou WC, Lin Z. (2020). Probabilistic human health risk assessment of perfluorooctane sulfonate (PFOS) by integrating in vitro, in vivo toxicity, and human epidemiological studies using a Bayesian-based dose-response assessment coupled with physiologically based pharmacokinetic (PBPK) modeling approach. Environment International, 137:105581. [PMID: 32087483] Access Model Code | Link to Article | Link to PDF file
19. Cheng YH, He C, Riviere JE, Monteiro-Riviere NA,Lin Z. (2020). Meta-analysis of nanoparticle delivery to tumors using a physiologically based pharmacokinetic modeling and simulation approach. ACS Nano, 14, 3, 3075-3095. [PMID: 32078303] Access Model Code | Link to Article | Link to PDF file
