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Institute of Computational Comparative Medicine

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Colorado State University Professor Emeritus Dr. Raymond Yang visits the ICCM
Colorado State University Professor Emeritus Dr. Raymond Yang visited the ICCM April 4th and 5th as a guest lecturer in Dr. Zhoumeng Lin’s on-line physiological based pharmacokinetic (PBPK) modeling course. Dr. Yang is widely considered as one of the founding fathers of PBPK modeling. In addition, he interacted closely with ICCM faculty and post-doctoral fellows, reviewed ongoing projects and established what should become fruitful collaborations in the future. 
Yang-ICCM
The Nanotechnology Innovation Center and the Institute of Computational Comparative Medicine Faculty and Postdoctoral Awards, Grants, Book Chapters, and Invited Presentations from January 2016 - April 2016.

Honors and Awards: 

  1. Dr. Nancy Monteiro-Riviere was selected as an “Eminent Toxicologist” because of her major contribution to the science of toxicology and engaging ability as a public speaker. Her lecture on “Frontiers in Nanotoxicology of the Skin” was videotaped and archived in the Eminent Toxicologist Series to incorporate prominent toxicologists who have created history.  
  2. Dr. KuKanich served on the KSU’s Mentoring Fellowship program for Dr. Eshar on the grant: “Pharmacokinetics of one antibiotic drug (enrofloxacin) and one analgesic/anti-inflammatory drug (meloxicam) in zoo-kept black-tailed prairie dogs”.
  3. Dr. Aryal, Graduate Student Summer Stipend for $ 4807.00 for T.Nguyen. Ms. Nguyen received the Phi Lambda Upsilon award.
  4. Dr. A. Pitchaimani, a postdoctoral fellow under Dr. Aryal received a $1000 travel award.
  5. Dr. Nancy Monteiro-Riviere was Chairperson of the Alternative In Vitro Toxicity Models Session at The 55th Annual Meeting of the National Society of Toxicology, New Orleans, LA. March 16, 2016.
  6. Dr. Parwathy Chandran, a postdoctoral fellow under Dr. Nancy Monteiro-Riviere received the Outstanding Postdoctoral Award at the Nanotoxicology Specialty Section at the 55th National Society of Toxicology, New Orleans, LA, March16, 2016.
  7. Drs. Lin, Monteiro-Riviere NA, Riviere JE received an Honorable Mention for best paper from the Biological Modeling Specialty Section of the National Society of Toxicology entitled “A physiologically based pharmacokinetic model for polyethylene glycol-coated gold nanoparticles of different sizes in adult mice”. Nanotoxicology 10(2):162-172, 2016.
  8. Drs. Lin, Monteiro-Riviere NA, Riviere JE publication “Pharmacokinetics of metallic nanoparticles” in WIREs Nanomedicine and Nanobiotechnology, 7(2):189-217, 2015 was listed in the Top Ten most accessed paper.
  9. Dr. Nancy Monteiro-Riviere was Chair of the National Institute of Environmental Health Sciences (NIEHS) Special Emphasis Panel on Engineered Nanomaterials Grant Applications UO1. April, 2016.
  10. Dr. Jim Riviere completed a year-long critical review of the USDA/FSIS National Residue Program for Meat, Poultry and Egg Products (2014-2015) released by the Pew Charitable Trusts on March 8, 2016.
  11. Patrick Guvele, an undergraduate student working in Dr. Monteiro-Riviere’s lab at the NICKS Center, received an Honorable Mention at the 16th Annual Developing Scholars Program Research Symposium at KSU on April 17, 2016. 

Book Chapters: 

  1. Samberg ME, Lin Z, Monteiro-Riviere NA. In Vitro and In Vivo Toxicity and Pharmacokinetics of Silver Nanoparticles. In Encyclopedia of Nanotechnology (Ed. Bhushan, B.). Springer Science and Business Media, Dordrecht, pp.1-14, 2015. DOI: 10.1007/978-94-007-6178-0_331-2 
  1. Narayan RJ, Boehm RD, Monteiro-Riviere NA. Cell and Protein Interactions with Diamond.  In  Handbook of Clinical Medicine-Law, Business, Regulation, Safety and Risk, (Eds. Bawa R, Audette G, Reese BE), Vol.11, Section III-Health, Safety, Risk and Biological Interactions, Pan Stafford Publishing, Singapore, Chapter 33, pp.809-822, 2016.
  2. Monteiro-Riviere NA. Safety of Nanoparticle Skin Penetration. In Percutaneous Penetration Enhancers-Chemical Methods in Penetration Enhancement-Nanocarriers Series (Eds. Dragicevic N and Maibach HI), Springer-Verlag Publishers, Heidelberg, Germany, Vol. 2, Chapter 24, pp. 363-376, 2016.

Abstracts: 

  1. Choi K, Koci J, Ortega MT, Jeffery B, Riviere JE, Monteiro-Riviere NA. Mechanistic toxicity assessment of hexahydroisohumulone incanine hepatocytes, renal proximal tubules, and enterocyte like-cells.  The Toxicologist 150, p.487, #3078, 2016. 
  2. Monteiro-Riviere NA, Ortega MT, Koci J, Lin Z, Jeffery B, Riviere JE. Comparative in vitro cytotoxicity of 20 potential food ingredients in canine liver, kidney, bone marrow-derived mesenchymal stem cells and enterocyte-like cells. The Toxicologist 150, p.487-488, #3079, 2016.
  3. Sasidharan A, Monteiro-Riviere NA. Impact of the protein corona on the blood compatibility profile of gold nanoparticles. The Toxicologist 150, p.415, #2766, 2016.
  4. Chandran P, Monteiro-Riviere NA. The effect of protein corona formation on the intracellular uptake profiles of gold nanoparticles in human primary vascular endothelial cells. The Toxicologist 150, p.413-414, #2760, 2016.
  5. Zhang LO, Li J, He X, Lv X, Chen D, Li L, Chen C, Zhao Y, Wang F, Monteiro-Riviere NA, Guo Z. Mitochondria-targeted platinum coordination compounds may increase cell adhesion and inhibit migration. The Toxicologist 150, p.154, #1656, 2016.
  6. Lin Z, Monteiro-Riviere NA, Kannan R, Riviere JE. A computational framework for interspecies pharmacokinetics, exposure and toxicity assessment of gold nanoparticles. The Toxicologist 150, p.117, #1504, 2016.
  7. Muhammad F, Jaberi-Douraki M, de Souza D, Riviere JE. modulation of chemical dermal absorption by 14 natural products: a quantitative structure permeation (QSPR) analysis of components often found in topical cosmeceuticals. The Toxicologist 150, p. 590, #3512, 2016.
  8. Nguyen T, Pitchaimani A, Koirala M, Aryal S. Engineering Biomimetic Nanoabsorbent for Detoxification of Chemotherapeutics. Capitol Graduate Research Summit, Topeka, KS, February 2, 2016.
  9. Sridibhatla S, Nguyen T, Pitchaimani A, Koirala M, Aryal S. Bisphosphonate functionalized nanomedicine for targeting bone microenvironment. Capitol Graduate Research Summit, Topeka, KS, February 2, 2016.
  10. Nguyen T, Pitchaimani A, Wang H, Bossmann S, Aryal S. Bone microenvironment targeted magnetic nanomedicine.  K-State Graduate Research, Arts, and Discovery(GRAD) Forum, KSU,    Manhattan, KS, March 2016.     
  11. Inchun N, Curtis C, Thomas S, Marroquin S, Hurst M, DeLong RK. Characterization of the interactions between model RNA, protein, and bio-relevant nanoparticles. ERN-Emerging Researchers National Conference in STEM, Washington, DC, 274:A239, 2016.
  12. Ramani M and DeLong RK.Absorption mechanisms of poly I: c RNA onto zinc oxide   nanoparticles:maximizing the payload. Experimental Biology 823.4: 261, 2016.
  13. Thomas S, Marroquin S, DeLong RK. Elucidating the dynamics of nanoparticle-protein interaction at a biomolecular level: structural and functional studies using firefly luciferase.  Experimental Biology  969.34: 323, 2016.
  14. Wang H, Chen R, Chen L, Qiu P, Xu J, Huang E, Liu C, Lin Z, Xie W. DNA damage-inducible transcript 4 (DDIT4) mediates methamphetamine-induced autophagy and apoptosis through mTOR signaling pathway in cardiomyocytes. The Toxicologist, 150, p. 433, #2843, 2016.
  15. Xie W, Cai D, Qiao D, Yue X, Wang Q, Li D, Lin Z, Wang H. Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. The Toxicologist, 150, p. 78, #1329, 2016.

Invited Presentations: 

1.   Dr. Aryal “Rational Design of Polymeric Nanoparticle as a Theranostic Device”, Chonbuk National University, Jeonju, South Korea, April 2, 2016.

2.   Dr. Aryal “Polymeric Nanomedicine as a Therapeutic and Diagnostic Modality”, Yonsei University, Wonju, South Korea, April 4, 2016.

3.   Dr. Aryal “Polymeric Nanomedicine for Targeting Bone Microenvironment”, Polymer Society of Korea, Daejeon, South Korea, April 8, 2016.

The 55th Annual Meeting of the National Society of Toxicology, New Orleans, L.A. March, 2016

The following Abstracts were presented: 

  1. Choi K, Koci J, Ortega MT, Jeffery B, Riviere JE, Monteiro-Riviere NA. Mechanistic toxicity assessment of hexahydroisohumulone incanine hepatocytes, renal proximal tubules, and enterocyte like-cells.  The Toxicologist 150, p.487, #3078, 2016. 
  2. Monteiro-Riviere NA, Ortega MT, Koci J, Lin Z, Jeffery B, Riviere JE. Comparative in vitro cytotoxicity of 20 potential food ingredients in canine liver, kidney, bone marrow-derived mesenchymal stem cells and enterocyte-like cells. The Toxicologist 150, p.487-488, #3079, 2016.
  3. Sasidharan A, Monteiro-Riviere NA. Impact of the protein corona on the blood compatibility profile of gold nanoparticles. The Toxicologist 150, p.415, #2766, 2016.
  4. Chandran P, Monteiro-Riviere NA. The effect of protein corona formation on the intracellular uptake profiles of gold nanoparticles in human primary vascular endothelial cells. The Toxicologist 150, p.413-414, #2760, 2016.
  5. Zhang LO, Li J, He X, Lv X, Chen D, Li L, Chen C, Zhao Y, Wang F, Monteiro-Riviere NA, Guo Z. Mitochondria-targeted platinum coordination compounds may increase cell adhesion and inhibit migration. The Toxicologist 150, p.154, #1656, 2016.
  6. Lin Z, Monteiro-Riviere NA, Kannan R, Riviere JE. A computational framework for interspecies pharmacokinetics, exposure and toxicity assessment of gold nanoparticles. The Toxicologist 150, p.117, #1504, 2016.
  7. Muhammad F, Jaberi-Douraki M, de Souza D, Riviere JE. modulation of chemical dermal absorption by 14 natural products: a quantitative structure permeation (QSPR) analysis of components often found in topical cosmeceuticals. The Toxicologist 150, p. 590, #3512, 2016. 

The following Honors and Awards were received: 

  1. Dr. Nancy Monteiro-Riviere was selected as an “Eminent Toxicologist” because of her major contribution to the science of toxicology and engaging ability as a public speaker. Her lecture on “Frontiers in Nanotoxicology of the Skin” was videotaped and archived in the Eminent Toxicologist Series to incorporate prominent toxicologists who have created history.  
  2. Dr. Nancy Monteiro-Riviere was Chairperson of the Alternative In Vitro Toxicity Models Session at The 55th Annual Meeting of the National Society of Toxicology, New Orleans, LA. March 16, 2016.
  3. Dr. Parwathy Chandran, a postdoctoral fellow under Dr. Nancy Monteiro-Riviere received the Outstanding Postdoctoral Award at the Nanotoxicology Specialty Section at the 55th National Society of Toxicology, New Orleans, LA, March16, 2016.
  4. Drs. Lin, Monteiro-Riviere NA, Riviere JE received an Honorable Mention for best paper from the Biological Modeling Specialty Section of the National Society of Toxicology entitled “A physiologically based pharmacokinetic model for polyethylene glycol-coated gold nanoparticles of different sizes in adult mice”. Nanotoxicology 10(2):162-172, 2016.
  5. Drs. Lin, Monteiro-Riviere NA, Riviere JE publication “Pharmacokinetics of metallic nanoparticles” in WIREs Nanomedicine and Nanobiotechnology, 7(2):189-217, 2015 was listed in the Top Ten most accessed paper.
Experts Visit New Zealand (pdf)
Pair of Kansas State University faculty members cover the topic of CLC transport proteins in latest physiology journal
Pair of Kansas State University faculty members cover the topic of CLC transport proteins in latest physiology journal

The Sept. 15 issue of The Journal of Physiology highlights Peying Fong and Jeffrey Comer from the College of Veterinary Medicine's anatomy and physiology department for their independent contributions on the featured topic of CLC — or chloride channel — transport proteins.

ICCM Group

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