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Institute of Computational Comparative Medicine


Kleinhenz MD, Van Engen NK, Gorden PJ, KuKanich B, Rajewski SM, Walsh P, Coetzee JF. The pharmacokinetics of transdermal flunixin meglumine in Holstein calves. J Vet Pharmacol Ther 9(6):612-615, 2016.

KuKanich B, Warner M, Hahn K. Analysis of lomustine drug content in FDA-approved and compounded lomustine capsules. J Am Vet Med Assoc  250(3):322-326, 2017.

Muhammad F, Nguyen TDT, Raza A, Akhtar B,Aryal S. A review on nanoparticle-based technologies for biodetoxification. Drug and Chem Toxicol 1-9, 2017.

Sidhu PK, Gehring R, Mzyk DA, Marmulak T, Tell LA, Baynes RE, Vickroy TW, Riviere JE. Avoiding violative flunixin meglumine residues in cattle and swine. J Am Vet Med Assoc 250(2):182-189, 2017.

Suarez MA, Seddighi R, Egger CM, Rohrbach BW, Cox SK, KuKanich BK, Doherty TJ. Effect of fentanyl and lidocaine on the end-tidal sevoflurane concentration preventing motor movement in dogs. Am J Vet Res 78(1):12-16, 2017.

Wen X, Gehring R, Stallbaumer A, Riviere JE, Volkova VV. Limitations of MIC as sole metric of pharmacodynamic response across the range of antimicrobial susceptibilities within a single bacterial species. Sci Rep 6:37907, 2016.

Lin Z, Monteiro-Riviere NARiviere JE. A physiological based pharmacokinetic model for polyethylene glycol-coated gold nanoparticles of different sizes in adult mice. Nanotoxicology 10: 162-172, 2016. 

Lin ZMonteiro-Riviere NA, Kanan R, Riviere JE. A computational framework for interspecies pharmacokinetics, exposure and risk assessment of gold nanoparticles. Nanomedicine 11: 107-119, 2016.

Shelver WL, Smith DJ, Tell LA, Baynes RE, Schroeder JW, Riviere JE. Screening and confirmatory analysis of flunixin in tissues and bodily fluids after intravenous or intramuscular administration of flunixin to cull dairy cows with or without lipopolysaccharide challenge. Journal Agricultural Food Chemistry 64 (1): 336-345, 2016.

DeDonder KD, Apley MD, Gehring R, Harhay DM, Lubbers BU, White BJ, Capik SF, KuKanich BRiviere JE, Tessman RK. Pharmacokinetics and pharmacodynamics of gamithromycin in pulmonary epithelial lining fluid in naturally occurring bovine respiratory disease in multi-source commingled feedlot cattle. Journal of Veterinary Pharmacology Therapeutics 39: 157-166, 2016. 

DeDonder KD, Gehring RRiviere JE, Baynes RE, Tell LA, Vickroy TW. Residue concerns following exposure to livestock to oil and petroleum products. Letter. Journal of the  American Veterinary Medical  Association.248: 145-146, 2016.

Choi K, Koci J, Ortega MT, Jeffery B, Riviere JEMonteiro-Riviere NA. Mechanistic toxicity assessment of hexahydroisohumulone in canine hepatocytes, renal proximal tubules, bone marrow-derived mesenchymal stem cells and enterocyte-like cells. International Journal of Veterinary Health Science and Research (IJVHSTR) 4 (2): 88-103, 2016.

Baynes RE, Dedonder K, Kissell L, Mzyk D, Marmulak T, Smith G, Tell L, Gehring R, Davis J, Riviere JE. Health concerns and management of select veterinary drug residues. Food Chemical Toxicology 88:112-122, 2016.

Seeley KE, Wolf KN, Bishop MA, Turnquist M, KuKanich B. Pharmacokinetics of long-acting cefovecin in copper rockfish. American Journal Veterinary Research 77(3):260- 264, 2016.

KuKanich K, KuKanich B, Guess S, Heinrich E. Effect of sucralfate on the relative bioavailability of enrofloxacin and ciprofloxacin in healthy fed dogs. Journal of Veterinary Internal Medicine 30(1):108-115, 2016.

Gorden PJ, Kleinhenz MD, Wulf LW, KuKanich B, Lee CJ, Wang C, Coetzee JF. Altered plasma pharmacokinetics of ceftiofur hydrochloride in cows affected with severe clinical mastitis. Journal of Dairy Science 99(1):505-514, 2016.

Rankin AJ, Lanuza R, KuKanich B, Crumley WC, Pucket JD, Allbaugh RA, Meekins JM. Measurement of plasma gentamicin concentrations postchemical ciliary body ablation in dogs with chronic glaucoma. Veterinary Ophthalmology 19(1):57-62, 2016.

Choi K, Ortega MT, Jeffery B, Riviere JE, Monteiro-Riviere NA. Oxidative stress response in canine in vitro liver, kidney, and intestinal models with seven potential dietary ingredients. Toxicology Letters 241: 49-59, 2016.

Ortega MT, Jeffery B, Riviere JE, Monteiro-Riviere NA. Toxicological effect of pet food ingredients on canine bone marrow derived mesenchymal stem cells and enterocyte-like cells. Journal Applied Toxicology 36 (2): 189-198, 2016.

Lin Z, Cuneo M, Rowe JD, Li M, Tell LA, Allison S, Carlson J, Riviere JE, Gehring R. (2016). Estimation of tulathromycin depletion in plasma and milk after subcutaneous injection in lactating goats using a nonlinear mixed-effects pharmacokinetic modeling approach. BMC Veterinary Research 12:258, 2016.

Lin Z, Gehring R, Mochel JP, Lavé T, Riviere JE. Mathematical modeling and simulation in animal health - Part II: principles, methods, applications, and value of physiologically based pharmacokinetic modeling in veterinary medicine and food safety assessment. Journal of Veterinary Pharmacology and Therapeutics 39:421-438, 2016.

Volkova VV, KuKanich B, Riviere JE. Exploring post-treatment reversion of antimicrobial resistance in enteric bacteria of food animals as a resistance mitigation strategy. Foodborne Pathogens Disease 13(11): 610-617, 2016.

Chen R, Zhang Y, Monteiro-Riviere NA, Riviere JE. Quantification of nanoparticle pesticide absorption: computational approaches based on experimental data. Nanotoxicology 10 (8):1118-1128, 2016.

Chittenden JT, Riviere JE. Assessment of penetrant and vehicle mixture properties on transdermal permeability using a mixed effect pharmacokinetic model of ex vivo porcine skin. Biopharmaceutics Drug Disposition 37: 387-396, 2016.

Smith D, Shelver W, Baynes R, Tell L, Gehring R, Li M, Dutko T, Schroeder JW, Herges G, Riviere JE. Excretory, Secretory, and Tissue Residues after Label and Extra-label Administration of Flunixin Meglumine to Saline- or Lipopolysaccharide-Exposed Dairy Cows. J. Agric. Food Chem., 63, 4893-4901, 2015.

Haung Q, Gehring R, Tell LA, Li M, Riviere JE. Interspecies allometic meta-analysis of the comparative pharmacokinetics of 85 drugs across veterinary and laboratory animal species. J.vet. Pharmco.Therap.,38:214-226, 2015

Sahneh FD, Scoglio C, Monteiro-Riviere MA, Riviere JE. Predicting the impact of biocorona formation kinetics on interspecies extrapolation of nanoparticle biodistribution. Nanomedicne (London), 10: 25-33, 2015 

Lin Z, Li M, Gehring R, Riviere JE. Development and application of a multi-route physiological based pharmacokinetic model for oxytetracycline in dogs and humans. J. Pharm. Sci. 104: 233-243, 2015

Chen R, Zhang Y, Sahneh F, Scoglio CM, Wohlleben W, Haase A, Monteiro-Riviere NA, Riviere JE. Nanoparticle surface characterization and clustering through concentration-dependent surface adsorption modeling. ACS Nano 8: 9446-9456, 2014.

Li M., Gehring R., Tell L., Baynes R., Huang Q., Riviere, J.E. Interspecies Mixed-Effect Pharmacokinetic Modeling of Penicillin G in Cattle and Swine. Antimicrob Agents Chemother, 58(8), 4495-4503,2014.

Huang Q, Riviere J.E. :The application of allometric scaling principles to predict pharmacokinetic parameters across species. Expert Opin Drug Metab Toxicol, 1-13, 2014.

DeDonder K, Gehring R, Baynes RE, Tell L, Vickroy TW, Apley MD, Riviere JE Procaine penicillin G withdrawal intervals for cattle: An update based on new sampling protocols. Journal of the Veterinary Medical Association 2013 (In press)

Karadzovska D, Brooks JD, Riviere JE. Modeling the effect of experimental variables on the in vitro permeation of six model compounds across porcine skin. Int. J. Pharm. 443: 58-67, 2013.

Wu H, Leavens T, Baynes RE, Tell LA, Riviere JE. Use of population pharmacokinetic modeling and Monte Carlo simulations to capture individual animal variability in the prediction of flunixin withdrawal times in cattle. J. Vet. Pharmacol. Therap. 36: 248-257, 2013.

Sahneh FD, Scoglio C, Riviere JE. Dynamics of nanoparticle-protein corona complex. Analytical results from population balance equations. PlosOne. 8: e64690, 2013.

Monteiro-Riviere NA, Samberg ME, Oldenburg SJ, Riviere JE. Protein binding modulates the cellular uptake of silver nanoparticles into human cells: Implications for in vitro to in vivo extrapolations. Toxicol. Letters. 220: 286-293, 2013.

Karadzovska D, Riviere JE. Assessing vehicle effects on skin absorption using membrane coated fiber arrays. Cut. Ocular Toxicol. 32: 283-289, 2013.

Riviere JE. Of mice, men and nanoparticle biocoronas: Are in vitro-in vivo correlations and interspecies extrapolations realistic? Nanomedicine. 8:1357-1359, 2013.

Soliman AM, Youssef SAH, Amer AM, Abu-Basha E, Murphy PA, Hauck CC, Gehring R, Hsu WH Effect of chronic lead intoxication on the absorption and disposition of amoxicillin in goats. Journal of Veterinary Sciences, 2013 (E-pub ahead of print)

Buckley GJ, Riviere JE, Gostin LO. What to do about unsafe medicines? Brit. Med. J. 347: f5064, 2013.

Riviere JE, Scoglio C, Sahneh F, Monteiro-Riviere NA. Computational Approaches and Metrics Needed for Formulating Biologically Realistic Nanomaterial Pharmacokinetic Models. Computational Sci. Discovery. 6:014005, 2013.

Chiesa OA, Idowu OR, Heller D, Smith M, Nochetto C, Chamberlain PL, Gehring R, von Bredow J A holstein cow-calf model for the transfer of ciprofloxacin through milk after a long-term intravenous infusion. Journal of Veterinary Pharmacology and Therapeutics. 2012 (E-pub ahead of print)

Malreddy PR, Coetzee JF, KuKanich B, Gehring R Pharmacokinetics and milk secretion of gabapentin and meloxicam co-administered orally in Holstein-Fresian cows. Journal of Veterinary Pharmacology and Therapeutics, 2012 36 (1): 14-20

Karadzovska D, Riviere JE. Assessing vehicle effects on skin absorption using artificial membrane assays. Eur. J. Pharm. Sci. doi:10.1016/jejps.2013.02.020

Shelver WL, Tell LA, Wagner S, Wetzlich S, Baynes RE, Riviere JE, Smith DJ. Comparison of ELISA and LC-MS/MS for the measurement of flunixin free acid plasma concentrations in beef cattle after intravenous and subcutaneous administration. J. Ag. Food  Chem. Doi:10.1021/jf304773p

Mochel JP, Gabrielsson J, Collard W, Fink M, Gehring R, Laffont C, Liu Y, Martin-Jimenez T, Pelligrand L. Steiner J-L, Toutain PL, Whittem T, Riviere JE. Animal Health Modeling and Simulation Society (AHM&S): A new society promoting model-based approaches in veterinary pharmacology. J. Vet. Pharmacol. Therap. Doi:10.111/jvp.12060.

Gehring R, Riviere JE. Limitations of MIC as the sole criteria in antimicrobial drug dosage regimen design: Need for full characterization of antimicrobial pharmacodynamic profile especially in drug-resistant organisms. The Veterinary Journal. Doi:10.1016/j.tvj1.2013.07.034

Carter SG, Zhu Z, Varodi G, Veves A, Riviere JE. Vasomodulation influences on the transdermal delivery of ibuprofen. J. Pharm. Sci. doi: 10.1002/jps.23719.


ICCM Group


John Doull Award

Dr. Jim Riviere was awarded  “The John Doull Award” from the Central States Society of Toxicology Read more

ICCM Announces first two KSU Faculty Cluster Appointments: Dr. Jeffrey Comer and Dr. Victoriya Volkova  Read more

ICCM Construction complete:

ICCM New Facility Area

Construction on the new ICCM facilities is complete and staff is now settling in.

Dr. Jim RiviereExpert Exchange
Dr. Jim Riviere

University clinical pharmacologist collaborates with international colleagues about chronic lead intoxication in goats  Read More