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Institute of Computational Comparative Medicine

PBPK Models

1. Lin Z, Li M, Gehring R, Riviere JE. Development and application of a multiroute physiologically based pharmacokinetic model for oxytetracycline in dogs and humans. Journal of Pharmaceutical Sciences. 2015;104(1):233-43. doi: 10.1002/jps.24244. Access Model Code | Link to Article

2. Huang L, Lin Z, Zhou X, Zhu M, Gehring R, Riviere JE, Yuan Z. Estimation of residue depletion of cyadox and its marker residue in edible tissues of pigs using physiologically based pharmacokinetic modelling. Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment. 2015;32(12):2002-17. doi: 10.1080/19440049.2015.1100330. Access Model Code | Link to Article | Link to PDF file

3. Lin Z, Monteiro-Riviere NA, Riviere JE. A physiologically based pharmacokinetic model for polyethylene glycol-coated gold nanoparticles of different sizes in adult mice. Nanotoxicology. 2016;10(2):162-72. doi: 10.3109/17435390.2015.1027314. Access Model Code | Link to Article | Link to PDF file

4. Lin Z, Monteiro-Riviere NA, Kannan R, Riviere JE. A computational framework for interspecies pharmacokinetics, exposure and toxicity assessment of gold nanoparticles. Nanomedicine (Lond). 2016;11(2):107-19. doi: 10.2217/nnm.15.177. Access Model Code | Link to Article | Link to PDF file

5. Lin Z, Vahl CI, Riviere JE. Human food safety implications of variation in food animal drug metabolism. Scientific Reports. 2016;6:27907. doi: 10.1038/srep27907. Access Model Code | Link to Article | Link to PDF file

6. Lin Z, Jaberi-Douraki M, He C, Jin S, Yang RSH, Fisher JW, Riviere JE. Performance assessment and translation of physiologically based pharmacokinetic models from acslX to Berkeley Madonna, MATLAB, and R language: oxytetracycline and gold nanoparticles as case examples. Toxicological Sciences, 2017;158(1):23-35. doi: https://doi.org/10.1093/toxsci/kfx070. [PMID: 28402537] Access Model Code | Link to Article | Link to PDF file

7. Li M, Gehring R, Riviere JE, Lin Z. Development and application of a population physiologically based pharmacokinetic model for penicillin G in swine and cattle for food safety assessment. Food and Chemical Toxicology, 2017;107:74-87. doi: 10.1016/j.fct.2017.06.023. [PMID: 28627373] Access Model Code | Link to Article | Link to PDF file

8. Zeng D, Lin Z, Fang B, Li M, Gehring R, Riviere JE, Zeng Z. Pharmacokinetics of mequindox and its marker residue 1,4-bisdesoxymequindox in swine following multiple oral gavage and intramuscular administration: an experimental study coupled with population physiologically based pharmacokinetic modeling. Journal of Agricultural and Food Chemistry, 2017;65(28):5768-5777. doi: 10.1021/acs.jafc.7b01740. [PMID: 28640606] Access Model Code | Link to Article | Link to PDF file

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News

John Doull Award

Dr. Jim Riviere was awarded  “The John Doull Award” from the Central States Society of Toxicology Read more

ICCM Announces first two KSU Faculty Cluster Appointments: Dr. Jeffrey Comer and Dr. Victoriya Volkova  Read more

ICCM Construction complete:

ICCM New Facility Area

Construction on the new ICCM facilities is complete and staff is now settling in.

Dr. Jim RiviereExpert Exchange
Dr. Jim Riviere

University clinical pharmacologist collaborates with international colleagues about chronic lead intoxication in goats  Read More