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Institute of Computational Comparative Medicine

Dr. Jim E. Riviere

Jim RiviereMacDonald Endowed Chair in Veterinary Medicine
Kansas Bioscience Eminent Scholar
University Distinguished Professor


1976 B.S. Biology; M.S. Endocrinology, Boston College
1980 D.V.M., Purdue University
1980 Ph.D. Pharmacology, Purdue University
2007 D.Sc. (honoris causa), Purdue University
Elected Member, Institute of Medicine of the National Academies


(785) 532-3683

  • Mathematical modeling and pharmacokinetics of drug, chemical and nanomaterial ADME and disposition.
  • Interspecies allometry.
  • Pharmacokinetics and QSAR of dermal absorption of complex mixtures.
  • Developing biologically relevant metrics of nanomaterial biodistribution.
  • Global chemical food safety.
Selected Publications

Choi K, Riviere JE, Monteiro-Riviere NA. Protein corona modulation of hepatocyte uptake and molecular mechanisms of gold nanoparticle toxicity. Nanotoxicology  11(1):64-75, 2017. 

Chen R, Riviere JE. Biological surface adsorption index of nanomaterials: modelling surface interactions of nanomaterials with biomolecules. Adv Exp Med Biol 947:207-253, 2017.

Ramani M, Mudge MC, Morris RT, Zhang Y, Warcholek SA, Hurst MN, Riviere JE, DeLong RK.  Zinc oxide nanoparticle-poly I:C RNA complexes: implication as therapeutics against experimental melanoma. Mol Pharm  2017.

Sidhu PK, Gehring R, Mzyk DA, Marmulak T, Tell LA, Baynes RE, Vickroy TW, Riviere JE. Avoiding violative flunixin meglumine residues in cattle and swine. J Am Vet Med Assoc 250(2):182-189, 2017.

Wen X, Gehring R, Stallbaumer A, Riviere JE, Volkova VV. Limitations of MIC as sole metric of pharmacodynamic response across the range of antimicrobial susceptibilities within a single bacterial species. Sci Rep 6:37907, 2016.

Lin Z, Vahl CI, Riviere JE. Human food safety implications of variation in food animal drug metabolism. Scientific Reports, 2016;6:27907.

Lin Z, Monteiro-Riviere NA, Riviere JE. A physiological based pharmacokinetic model for polyethylene glycol-coated gold nanoparticles of different sizes in adult mice. Nanotoxicology 10: 162-172, 2016.

Lin Z, Monteiro-Riviere NA, Kanan R, Riviere JE. A computational framework for interspecies pharmacokinetics, exposure and risk assessment of gold nanoparticles. Nanomedicine 11: 107-119, 2016.

Shelver WL, Smith DJ, Tell LA, Baynes RE, Schroeder JW, Riviere JE. Screening and confirmatory analysis of flunixin in tissues and bodily fluids after intravenous or intramuscular administration of flunixin to cull dairy cows with or without lipopolysaccharide challenge.Journal Agricultural Food Chemistry 64 (1): 336-345, 2016.

DeDonder KD, Apley MD, Gehring R, Harhay DM, Lubbers BU, White BJ, Capik SF, KuKanich B, Riviere JE, Tessman RK. Pharmacokinetics and pharmacodynamics of gamithromycin in pulmonary epithelial lining fluid in naturally occurring bovine respiratory disease in multi-source commingled feedlot cattle. Journal of Veterinary Pharmacology Therapeutics 39: 157-166, 2016.

DeDonder KD, Gehring R, Riviere JE, Baynes RE, Tell LA, Vickroy TW. Residue concerns following exposure to livestock to oil and petroleum products. Letter. Journal of the  American Veterinary Medical  Association. 248: 145-146, 2016.

Choi K, Koci J, Ortega MT, Jeffery B, Riviere JE, Monteiro-Riviere NA. Mechanistic toxicity assessment of hexahydroisohumulone in canine hepatocytes, renal proximal tubules, bone marrow-derived mesenchymal stem cells and enterocyte-like cells. International Journal of Veterinary Health Science and Research (IJVHSTR) 4 (2): 88-103, 2016.

Baynes RE, Dedonder K, Kissell L, Mzyk D, Marmulak T, Smith G, Tell L, Gehring R, Davis J, Riviere JE. Health concerns and management of select veterinary drug residues. Food Chemical Toxicology 88:112-122, 2016.

Choi K, Ortega MT, Jeffery B, Riviere JE, Monteiro-Riviere NA. Oxidative stress response in canine in vitro liver, kidney, and intestinal models with seven potential dietary ingredients. Toxicology Letters 241: 49-59, 2016.

Ortega MT, Jeffery B, Riviere JE, Monteiro-Riviere NA. Toxicological effect of pet food ingredients on canine bone marrow derived mesenchymal stem cells and enterocyte-like cells. Journal Applied Toxicology 36 (2): 189-198, 2016.

Lin Z, Li M, Gehring R, Riviere JE. Development and application of a multi-route physiological based pharmacokinetic model for oxytetracycline in dogs and humans. J. Pharm. Sci. 104: 233-243, 2015. 

Kissel LW, Leavens TL, Baynes RE, Riviere JE, Smith G. Comparison of flunixin pharmacokinetics and milk elimination in healthy cows and cows with mastitis. J. Am. Vet. Med. Assoc. 246: 118-125, 2015.

Riviere JE. Pharmacokinetics and Biodistribution of Nanomaterials. InNanotoxicology: Progress toward Nanomedicine. (Eds. Monteiro-Riviere NA and Tran CL), CRC Press, Boca Raton, Fl., Chapter 8, 135- 152, 2014.

Chittenden JT Brooks JD, Riviere JE. Development of a mixed-effect pharmacokinetic model for vehicle modulated in vitro transdermal flux of topically applied penetrants. Journal of Pharmaceutical Sciences 103:1002-1012, 2014.

Monteiro-Riviere NA, Riviere JE. Dermatotoxicity of Nanomaterials. InHandbook of Safety Assessment of Nanomaterials: From Toxicological Testing to Personalized Medicine. (Ed. Fadeel B.), Pan Stamford Press, Chapter 15, pp. 439-459, 2014.

Baynes RE, Riviere JE (eds): Strategies for Reducing Drug and Chemical Residues in Food Animals: International Approaches to Residue Avoidance, Management and Testing. New York: John Wiley, 2014.

Guth K, Riviere JE, Brooks JD, Schaefer-Korting M, Dammann M, Fabian JD, Van Ravenzwaay B, Landsiedal R: In silico models to predict dermal absorption from complex agrochemical formulations. SAR QSAR Environ. Res. 6: 1-24, 2014.

Baynes R, Riviere J: Importance of veterinary drug residues. In Baynes R, Riviere JE (eds): Strategies for Reducing Drug and Chemical Residues in Food Animals: International Approaches to Residue Avoidance, Management and Testing. New York: Wiley, pgs. 1-8, 2014.

Vickroy T, Baynes R, Tell L, Riviere J: The Food Animal Residue Avoidance databank: An example of risk management of veterinary drug residues. In Baynes R, Riviere JE (eds): Strategies for Reducing Drug and Chemical Residues in Food Animals: International Approaches to Residue Avoidance, Management and Testing. New York: Wiley, pgs. 289-302, 2014.

Baynes J, Riviere J: Risk management of chemical contaminants in livestock. In Baynes R, Riviere JE (eds): Strategies for Reducing Drug and Chemical Residues in Food Animals: International Approaches to Residue Avoidance, Management and Testing. New York: Wiley, pgs. 303-312, 2014.

Riviere JE, Brooks JD, Collard W, DeRose G, Mahabir S, Marchiondo AA: Prediction of formulation effects on dermal absorption of topically applied ectoparasiticides dosed in vitro on canine and porcine skin using a mixture-adjusted quantitative structure permeability relationship. J. Vet. Pharmacol. Therap. 37: 435-444, 2014.

Leavens TL, Tell LA, Kissell LW, Smith GW, Smith DJ, Wagner SA, Shelver WL, Wu H, Baynes RE, Riviere JE. Development of a physiologically based pharmacokinetic model for flunixin in cattle (Bos Taurus). Food Additives Contamin. Part A. 31: 1506-1521, 2014.

Li M., Gehring R., Tell L., Baynes R., Huang Q., Riviere, J.E. Interspecies Mixed-Effect Pharmacokinetic Modeling of Penicillin G in Cattle and Swine. Antimicrob Agents Chemother, 58(8), 4495-4503,2014.

Huang Q., Riviere J.E. :The application of allometric scaling principles to predict pharmacokinetic parameters across species. Expert Opin Drug Metab Toxicol, 1-13, 2014.

Riviere JE, Papich M (eds): Veterinary Pharmacology and Therapeutics, 9th Edition. Wiley-Blackwell, Ames, IA , 2009.

Xia XR, Monteiro-Riviere NA, Riviere JE: An index for characterization of nanomaterials in biological systems. Nature Nanotech. 5: 671-675, 2010. (Highlited in Nature Nanotech News and Views 5: 633-634, 2010; Nature News 467: 264-265, 2010).

Riviere JE: Comparative Pharmacokinetics: Principles, Techniques and Applications. 2nd Edition, Wiley-Blackwell, Ames, IA, 2011.

Riviere JE, Brooks JD: Predicting skin permeability from complex chemical mixtures: Dependency of quantuitative structure permeability relationships (QPSR) on biology of skin model used. Toxicol. Sci. 119: 224-232, 2011.

Xia XR, Monteiro-Riviere NA, Mathur S, Oldenberg S, Fadell B, Riviere JE. Mapping the surface adsorption forces of nanomaterials in biological systems using the biological surface adsorption index (BSAI) approach. ACS Nano 5: 9074-9081, 2011.

Leavens TL, Tell LA, Clothier KA, Griffith KA, Baynes RE, Riviere JE: Development of physiological based pharmacokinetic model to predict tulathromycin distribution in goats. J. Vet. Pharmacol. Therap. 35: 121-131, 2012.

Riviere JE, Leavens TL, Brooks JD, Monteiro-Riviere NA. Acute vascular effects of nanoparticle infusion in isolated perfused skin. Nanomedicine: Nanotech. Biol. Med.. 8: 428-431, 2012.

Karadzovska D, Brooks JD, Riviere JE. Experimental factors affecting in vitro absorption of six model chemicals across porcine skin. Toxicol. In Vitro. 26: 1191-1198, 2012.

Samaras EG, Riviere JE, Ghafourian T: The effects of formulations and experimental conditions on in vitro human skin penetration – Data from updated EDETOX database. Int. J. Pharmaceutics 434: 280-291, 2012.

Kissel LW, Smith GW, Leavens TL, Baynes RE, Wu H, Riviere JE. Plasma pharmacokinetics and milk residues of flunixin and 5-hydroxy flunixin following different routes of administration in dairy cattle. J. Dairy Sci. 95: 7151-7157, 2012.

Karadzovska D, Brooks JD, Monteiro-Riviere NA, Riviere JE. Predicting skin permeability from complex mixtures. Adv. Drug Del. Rev. 65: 265-277, 2013.

Karadzovska D, Brooks JD, Riviere JE. Modeling the effect of experimental variables on the in vitro permeation of six model compounds across porcine skin. Int. J. Pharm. 443: 58-67, 2013.

Wu H, Leavens T, Baynes RE, Tell LA, Riviere JE. Use of population pharmacokinetic modeling and Monte Carlo simulations to capture individual animal variability in the prediction of flunixin withdrawal times in cattle. J. Vet. Pharmacol. Therap. 36: 248-257, 2013.

Preston C, Azatyans S, Bell T, Bond K, Bradsher J, Brumfield M, Buckely G, Hughes T, kane S, Keramidas S, Miller M, Morrsion M, Rägol L, Riviere J, Valdez M, Wojtala G. Developing a global curriculum for regulators. Discussion Paper: Institute of Medicine, Washington, DC. 2013. http://iom.edu/Global/Perspectives/2013/GlobalCurriculum.aspx

Sahneh FD, Scoglio C, Riviere J. Dynamics of nanoparticle-protein corona complex. Analytical results from population balance equations. PlosOne. 8: e64690, 2013.

Monteiro-Riviere NA, Samberg ME, Oldenburg SJ, Riviere JE. Protein binding modulates the cellular uptake of silver nanoparticles into human cells: Implications for in vitro to in vivo extrapolations. Toxicol. Letters. 220: 286-293, 2013.

Riviere JE. Of mice, men and nanoparticle biocoronas: Are in vitro-in vivo correlations and interspecies extrapolations realistic? Nanomedicine. 8:1357-1359, 2013.

Buckley GJ, Riviere JE, Gostin LO. What to do about unsafe medicines? Brit. Med. J. 347: f5064, 2013.

Karadzovska D, Riviere JE. Assessing vehicle effects on skin absorption using artificial membrane assays. Eur. J. Pharm. Sci. doi:10.1016/jejps.2013.02.020

Shelver WL, Tell LA, Wagner S, Wetzlich S, Baynes RE, Riviere JE, Smith DJ. Comparison of ELISA and LC-MS/MS for the measurement of flunixin free acid plasma concentrations in beef cattle after intravenous and subcutaneous administration. J. Ag. Food Chem. Doi:10.1021/jf304773p

Mochel JP, Gabrielsson J, Collard W, Fink M, Gehring R, Laffont C, Liu Y, Martin-Jimenez T, Pelligrand L. Steiner J-L, Toutain PL, Whittem T, Riviere JE. Animal Health Modeling and Simulation Society (AHM&S): A new society promoting model-based approaches in veterinary pharmacology. J. Vet. Pharmacol. Therap. Doi:10.111/jvp.12060.

Gehring R, Riviere JE. Limitations of MIC as the sole criteria in antimicrobial drug dosage regimen design: Need for full characterization of antimicrobial pharmacodynamic profile especially in drug-resistant organisms. The Veterinary Journal. Doi:10.1016/j.tvj1.2013.07.034.

Carter SG, Zhu Z, Varodi G, Veves A, Riviere JE. Vasomodulation influences on the transdermal delivery of ibuprofen. J. Pharm. Sci. doi: 10.1002/jps.23719.

Riviere JE, Scoglio C, Sahneh F, Monteiro-Riviere NA. Computational Approaches and Metrics Needed for Formulating Biologically Realistic Nanomaterial Pharmacokinetic Models. Computational Sci. Discovery. Doi: 10.1088/1749-4699/6/1.*