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Veterinary Pharmacology and Therapeutics Journal


Kansas State University
228 Coles Hall
Manhattan, KS 66506


785-532-4557 fax

Dr. Jim E. Riviere

Jim RiviereMacDonald Endowed Chair in Veterinary Medicine
Kansas Bioscience Eminent Scholar
University Distinguished Professor


1976 B.S. Biology; M.S. Endocrinology, Boston College
1980 D.V.M., Purdue University
1980 Ph.D. Pharmacology, Purdue University
2007 D.Sc. (honoris causa), Purdue University
Elected Member, Institute of Medicine of the National Academies

(785) 532-3683
  • Mathematical modeling and pharmacokinetics of drug, chemical and nanomaterial ADME and disposition.
  • Interspecies allometry.
  • Pharmacokinetics and QSAR of dermal absorption of complex mixtures.
  • Developing biologically relevant metrics of nanomaterial biodistribution.
  • Global chemical food safety.
Selected Publications

Riviere JE, Papich M (eds): Veterinary Pharmacology and Therapeutics, 9th Edition. Wiley-Blackwell, Ames, IA , 2009.

Xia XR, Monteiro-Riviere NA, Riviere JE: An index for characterization of nanomaterials in biological systems. Nature Nanotech. 5: 671-675, 2010. (Highlited in Nature Nanotech News and Views 5: 633-634, 2010; Nature News 467: 264-265, 2010).

Riviere JE: Comparative Pharmacokinetics: Principles, Techniques and Applications. 2nd Edition, Wiley-Blackwell, Ames, IA, 2011.

Riviere JE, Brooks JD: Predicting skin permeability from complex chemical mixtures: Dependency of quantuitative structure permeability relationships (QPSR) on biology of skin model used. Toxicol. Sci. 119: 224-232, 2011.

Xia XR, Monteiro-Riviere NA, Mathur S, Oldenberg S, Fadell B, Riviere JE. Mapping the surface adsorption forces of nanomaterials in biological systems using the biological surface adsorption index (BSAI) approach. ACS Nano 5: 9074-9081, 2011.

Leavens TL, Tell LA, Clothier KA, Griffith KA, Baynes RE, Riviere JE: Development of physiological based pharmacokinetic model to predict tulathromycin distribution in goats. J. Vet. Pharmacol. Therap. 35: 121-131, 2012.

Riviere JE, Leavens TL, Brooks JD, Monteiro-Riviere NA. Acute vascular effects of nanoparticle infusion in isolated perfused skin. Nanomedicine: Nanotech. Biol. Med.. 8: 428-431, 2012.

Karadzovska D, Brooks JD, Riviere JE. Experimental factors affecting in vitro absorption of six model chemicals across porcine skin. Toxicol. In Vitro. 26: 1191-1198, 2012.

Samaras EG, Riviere JE, Ghafourian T: The effects of formulations and experimental conditions on in vitro human skin penetration – Data from updated EDETOX database. Int. J. Pharmaceutics 434: 280-291, 2012.

Kissel LW, Smith GW, Leavens TL, Baynes RE, Wu H, Riviere JE. Plasma pharmacokinetics and milk residues of flunixin and 5-hydroxy flunixin following different routes of administration in dairy cattle. J. Dairy Sci. 95: 7151-7157, 2012.

Karadzovska D, Brooks JD, Monteiro-Riviere NA, Riviere JE. Predicting skin permeability from complex mixtures. Adv. Drug Del. Rev. 65: 265-277, 2013.

Karadzovska D, Brooks JD, Riviere JE. Modeling the effect of experimental variables on the in vitro permeation of six model compounds across porcine skin. Int. J. Pharm. 443: 58-67, 2013.

Wu H, Leavens T, Baynes RE, Tell LA, Riviere JE. Use of population pharmacokinetic modeling and Monte Carlo simulations to capture individual animal variability in the prediction of flunixin withdrawal times in cattle. J. Vet. Pharmacol. Therap. 36: 248-257, 2013.

Preston C, Azatyans S, Bell T, Bond K, Bradsher J, Brumfield M, Buckely G, Hughes T, kane S, Keramidas S, Miller M, Morrsion M, Rägol L, Riviere J, Valdez M, Wojtala G. Developing a global curriculum for regulators. Discussion Paper: Institute of Medicine, Washington, DC. 2013. http://iom.edu/Global/Perspectives/2013/GlobalCurriculum.aspx

Sahneh FD, Scoglio C, Riviere J. Dynamics of nanoparticle-protein corona complex. Analytical results from population balance equations. PlosOne. 8: e64690, 2013.

Monteiro-Riviere NA, Samberg ME, Oldenburg SJ, Riviere JE. Protein binding modulates the cellular uptake of silver nanoparticles into human cells: Implications for in vitro to in vivo extrapolations. Toxicol. Letters. 220: 286-293, 2013.

Riviere JE. Of mice, men and nanoparticle biocoronas: Are in vitro-in vivo correlations and interspecies extrapolations realistic? Nanomedicine. 8:1357-1359, 2013.

Buckley GJ, Riviere JE, Gostin LO. What to do about unsafe medicines? Brit. Med. J. 347: f5064, 2013.

Karadzovska D, Riviere JE. Assessing vehicle effects on skin absorption using artificial membrane assays. Eur. J. Pharm. Sci. doi:10.1016/jejps.2013.02.020

Shelver WL, Tell LA, Wagner S, Wetzlich S, Baynes RE, Riviere JE, Smith DJ. Comparison of ELISA and LC-MS/MS for the measurement of flunixin free acid plasma concentrations in beef cattle after intravenous and subcutaneous administration. J. Ag. Food Chem. Doi:10.1021/jf304773p

Mochel JP, Gabrielsson J, Collard W, Fink M, Gehring R, Laffont C, Liu Y, Martin-Jimenez T, Pelligrand L. Steiner J-L, Toutain PL, Whittem T, Riviere JE. Animal Health Modeling and Simulation Society (AHM&S): A new society promoting model-based approaches in veterinary pharmacology. J. Vet. Pharmacol. Therap. Doi:10.111/jvp.12060.

Gehring R, Riviere JE. Limitations of MIC as the sole criteria in antimicrobial drug dosage regimen design: Need for full characterization of antimicrobial pharmacodynamic profile especially in drug-resistant organisms. The Veterinary Journal. Doi:10.1016/j.tvj1.2013.07.034.

Carter SG, Zhu Z, Varodi G, Veves A, Riviere JE. Vasomodulation influences on the transdermal delivery of ibuprofen. J. Pharm. Sci. doi: 10.1002/jps.23719.

Riviere JE, Scoglio C, Sahneh F, Monteiro-Riviere NA. Computational Approaches and Metrics Needed for Formulating Biologically Realistic Nanomaterial Pharmacokinetic Models. Computational Sci. Discovery. Doi: 10.1088/1749-4699/6/1.*